Key result
In patients with recent dilated cardiomyopathy, 56% had myocardial inflammation, and these patients exhibited significantly smaller left ventricular end-diastolic volumes compared to those without inflammation.
Why the study?
Do baseline clinical, echocardiographic, and hemodynamic parameters differ between patients with recent inflammatory versus non-inflammatory dilated cardiomyopathy?
Observational (n=50)
No
Do baseline clinical, echocardiographic, and hemodynamic parameters differ between patients with recent inflammatory versus non-inflammatory dilated cardiomyopathy?
Absolute Event Rate: 218% vs 262%
p-value: p=0.022
In patients with recent dilated cardiomyopathy, endomyocardial biopsy revealed an inflammatory etiology in 56% of cases, who presented with shorter symptom duration, smaller ventricular dimensions, and lower pulmonary pressures compared to those with non-inflammatory DCM.
May distinguish inflammatory DCM phenotype with less remodeling; leaves open whether biopsy alters management or outcomes.
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Krejčí et al. (2011) conducted an observational in Recent dilated cardiomyopathy (n=50). Inflammatory cardiomyopathy (ICM/ZKMP) vs. Non-inflammatory dilated cardiomyopathy (DCM) was evaluated on Left ventricular end-diastolic volume (EDV) in ml (p=0.022). In patients with recent dilated cardiomyopathy, 56% had myocardial inflammation, and these patients exhibited significantly smaller left ventricular end-diastolic volumes compared to those without inflammation.
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