Why the study?
Does the presence of inflammatory infiltration or viral genome in the myocardium affect the 6-month changes in echocardiographic parameters and NYHA class in patients with recent-onset dilated cardiomyopathy?
Observational (n=70)
No
Does the presence of inflammatory infiltration or viral genome in the myocardium affect the 6-month changes in echocardiographic parameters and NYHA class in patients with recent-onset dilated cardiomyopathy?
Absolute Event Rate: 14% vs 3.8%
p-value: p=0.0017
In patients with recent-onset non-ischemic LV dysfunction, biopsy-proven myocarditis is associated with significant improvement in LV function and functional status at 6 months, whereas the presence of viral genome does not significantly affect these outcomes.
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Krejčí et al. (2013) conducted an observational in Dilated cardiomyopathy (DCM) (n=70). Presence of myocardial inflammatory infiltration (IH+) vs. Absence of myocardial inflammatory infiltration (IH-) was evaluated on Change in left ventricular ejection fraction (LVEF) at 6 months (p=0.0017).
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