Key result
Pericyte RGS5 upregulation links to pulmonary microvascular remodeling in PAH.
Why the study?
Pulmonary vascular remodeling plays an important role in PAH, and identifying key driver genes regulating pulmonary microvascular remodeling is critical for PAH management.
Population
GEO datasets and PAH and normal mice
Comparison
PAH vs normal mice and datasets
Design
Bioinformatic and preclinical animal study
Authors
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Hypothesis-generating for pericyte-targeted approaches in PAH; prospective validation required before clinical consideration.
p-value: p=<0.001
Lu et al. (2023) studied Pulmonary arterial hypertension (n=113). RGS5 expression vs. Normal controls was evaluated on RGS5 expression levels and co-localization with pericytes (p=<0.001). RGS5 expression is significantly upregulated in pulmonary arterial hypertension tissues and co-localizes with pericytes, indicating its role in regulating pulmonary microvascular remodeling.
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