Why the study?
Does a single intraoperative dose of gentamicin and clindamycin reduce postoperative wound infection in patients undergoing emergency abdominal surgery?
Does a single intraoperative dose of gentamicin and clindamycin reduce postoperative wound infection in patients undergoing emergency abdominal surgery?
A single intraoperative dose of gentamicin and clindamycin significantly reduces postoperative wound infection in emergency abdominal surgery.
Reduces wound infections after emergency abdominal surgery; supports routine prophylaxis and further trials in other high-risk settings.
In a randomized controlled trial of the use of a single intravenous dose of gentamicin sulfate and clindamycin phosphate used intraoperatively during emergency abdominal surgery, the overall incidence of postoperative wound infection was reduced from 32.3% to 10.4%. Significant reduction in wound infection occurred in the study group compared with control subjects irrespective of the underlying pathologic lesion. No side effects of the use of antibiotics were noted. The policy of antibiotic prophylaxis in emergency surgery seems to be of particular benefit in elderly patients.
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Brian J. Rowlands (1982) studied this question.
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