What does this research mean for the field?

The clinical progression of heart failure is associated with increased cardiac Angiotensin II formation, while failing myocytes simultaneously lose the ability to synthesize IGF-I and ET-1 in response to Angiotensin II stimulation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to explore how cardiac angiotensin II generation is related to left ventricular function in patients with heart failure.

May 11, 2001Circulation ResearchOpen Access

Cardiac Angiotensin II Formation in the Clinical Course of Heart Failure and Its Relationship With Left Ventricular Function

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure (n=120). Intervention: Cardiac angiotensin II formation vs. Control subjects and nonfailing donor hearts. Primary outcome: Cardiac angiotensin II generation and its relationship with left ventricular function.

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Why the study?

How does cardiac angiotensin II formation change during the clinical course of heart failure, and what is its relationship with left ventricular function?

Population

76 patients with heart failure and 15 control subjects; additionally, 22 HF explanted hearts and 7…

Design

Cross-sectional

Key result

The clinical course of heart failure is associated with a progressive increase in cardiac Ang II formation, and failing myocytes are unable to synthesize IGF-I and ET-1 in response to Ang II.

Authors

GSGian Gastone Neri Serneri MBMaria Boddi ICIlaria Cecioni

Discussion

Member takes

Overview

Should not yet change HF management; leaves open whether cardiac Ang II is a modifiable driver of progression.

Key Points

This study aims to explore how cardiac angiotensin II generation is related to left ventricular function in patients with heart failure.
Investigated 76 heart failure patients and 15 control subjects through aorta-coronary sinus concentration gradients.
Examined gene expression of cardiac renin-angiotensin system components and myocyte growth factors in 22 explanted HF hearts and 7 nonfailing donor hearts.
Used binding studies to analyze AT(1) and AT(2) receptor densities in myocytes.
Cardiac angiotensin II generation increased with worsening heart failure; end-systolic wall stress was the only independent predictor.
Angiotensinogen and angiotensin-converting enzyme mRNA levels were elevated, while chymase levels remained unchanged.
Failing myocytes could not synthesize insulin-like growth factor-I and endothelin-1 in response to angiotensin II.

Study Design

Type

Observational (n=120)

Structured PICO

How does cardiac angiotensin II formation change during the clinical course of heart failure, and what is its relationship with left ventricular function?

Population

76 patients with heart failure (NYHA classes I through IV) and 15 control subjects; additionally, 22 HF explanted hearts (NYHA classes III and IV) and 7 nonfailing donor hearts.

Comparator

15 control subjects and 7 nonfailing donor hearts

Outcome

Cardiac angiotensin II (Ang II) generation and its relationship with left ventricular functionsurrogate

The clinical progression of heart failure is associated with increased cardiac Ang II formation driven by end-systolic wall stress, alongside a loss of myocyte responsiveness to Ang II for growth factor synthesis.

Cite This Study

Serneri et al. (2001) conducted an observational in Heart failure (n=120). Cardiac angiotensin II formation vs. Control subjects and nonfailing donor hearts was evaluated on Cardiac angiotensin II generation and its relationship with left ventricular function. The clinical course of heart failure is associated with a progressive increase in cardiac Ang II formation, and failing myocytes are unable to synthesize IGF-I and ET-1 in response to Ang II.

synapsesocial.com/papers/6a1c7b0d0e2acd31eb2fccd4 https://doi.org/10.1161/hh0901.089882

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May 11, 2001Circulation ResearchOpen Access

Cardiac Angiotensin II Formation in the Clinical Course of Heart Failure and Its Relationship With Left Ventricular Function

View Full Paper

Ask AI

Bookmark

Why the study?

How does cardiac angiotensin II formation change during the clinical course of heart failure, and what is its relationship with left ventricular function?

Population

76 patients with heart failure and 15 control subjects; additionally, 22 HF explanted hearts and 7…

Design

Cross-sectional

Key result

The clinical course of heart failure is associated with a progressive increase in cardiac Ang II formation, and failing myocytes are unable to synthesize IGF-I and ET-1 in response to Ang II.

Authors

GSGian Gastone Neri Serneri MBMaria Boddi ICIlaria Cecioni

Discussion

Member takes

Overview

Should not yet change HF management; leaves open whether cardiac Ang II is a modifiable driver of progression.

Key Points

This study aims to explore how cardiac angiotensin II generation is related to left ventricular function in patients with heart failure.
Investigated 76 heart failure patients and 15 control subjects through aorta-coronary sinus concentration gradients.
Examined gene expression of cardiac renin-angiotensin system components and myocyte growth factors in 22 explanted HF hearts and 7 nonfailing donor hearts.
Used binding studies to analyze AT(1) and AT(2) receptor densities in myocytes.
Cardiac angiotensin II generation increased with worsening heart failure; end-systolic wall stress was the only independent predictor.
Angiotensinogen and angiotensin-converting enzyme mRNA levels were elevated, while chymase levels remained unchanged.
Failing myocytes could not synthesize insulin-like growth factor-I and endothelin-1 in response to angiotensin II.

Study Design

Type

Observational (n=120)

Structured PICO

How does cardiac angiotensin II formation change during the clinical course of heart failure, and what is its relationship with left ventricular function?

Population

76 patients with heart failure (NYHA classes I through IV) and 15 control subjects; additionally, 22 HF explanted hearts (NYHA classes III and IV) and 7 nonfailing donor hearts.

Comparator

15 control subjects and 7 nonfailing donor hearts

Outcome

Cardiac angiotensin II (Ang II) generation and its relationship with left ventricular functionsurrogate

Cite This Study

synapsesocial.com/papers/6a1c7b0d0e2acd31eb2fccd4 https://doi.org/10.1161/hh0901.089882

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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