Key result
Low-dose aldosterone antagonists added to multidrug regimens provide significant additional blood pressure reduction in resistant hypertension, with breast tenderness occurring in about 10% of men.
Why the study?
Does low-dose aldosterone blockade reduce blood pressure in patients with resistant hypertension?
Population
Patients with resistant hypertension uncontrolled on multidrug regimens.
Design
Review
Authors
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Supports add-on use in resistant hypertension; leaves open confirmation by randomized trials.
Does low-dose aldosterone blockade reduce blood pressure in patients with resistant hypertension?
Low-dose aldosterone antagonists are an effective and generally safe add-on therapy for achieving blood pressure control in patients with resistant hypertension.
David A. Calhoun (2007) conducted a review in Resistant hypertension. Low-dose aldosterone antagonists (spironolactone) was evaluated on Blood pressure reduction. Low-dose aldosterone antagonists added to multidrug regimens provide significant additional blood pressure reduction in resistant hypertension, with breast tenderness occurring in about 10% of men.
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