Key result
Percutaneous pulmonary valve implantation significantly improved early LV diastolic filling from 17.5 to 30.4 mL/m2 (P<0.001) by reducing interventricular mechanical delay.
Why the study?
Does percutaneous pulmonary valve implantation improve left ventricular filling properties and exercise capacity in patients with congenital heart disease and right ventricle to pulmonary artery conduit obstruction?
Observational (n=20)
Does percutaneous pulmonary valve implantation improve left ventricular filling properties and exercise capacity in patients with congenital heart disease and right ventricle to pulmonary artery conduit obstruction?
Absolute Event Rate: 30.4% vs 17.5%
p-value: p=<0.001
Relief of right ventricle to pulmonary artery conduit obstruction via percutaneous pulmonary valve implantation improves early left ventricular filling properties and exercise capacity by reducing interventricular mechanical delay and improving septal motion.
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Associated with improved LV filling after PPVI in conduit obstruction; hypothesis-generating and requires randomized confirmation.
Lurz et al. (2009) conducted an observational in congenital heart disease and RV to PA conduit obstruction (n=20). percutaneous pulmonary valve implantation (PPVI) vs. baseline (before PPVI) was evaluated on early LV diastolic filling (first one-third of diastole) (p=<0.001). Percutaneous pulmonary valve implantation significantly improved early LV diastolic filling from 17.5 to 30.4 mL/m2 (P<0.001) by reducing interventricular mechanical delay.
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