What is the clinical evidence from this study?

Study design: Review. Population: Cardiac Arrhythmias.

January 1, 2009Circulation JournalOpen Access

From the Ryanodine Receptor to Cardiac Arrhythmias

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Key result

Arrhythmogenic calcium waves require a threshold sarcoplasmic reticulum calcium content to be exceeded, a threshold that is decreased by increasing ryanodine receptor open probability.

Design

Review

Authors

DEDavid EisnerElectrophysiology TKTakeshi KashimuraHeart Failure / Cardiomyopathy LVLuigi VenetucciUniversity of Manchester

Discussion

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Implication

Clarifies calcium wave triggers; leaves open whether ryanodine receptor modulation prevents clinical arrhythmias.

PICO

Population

Cardiac Arrhythmias

This review highlights that arrhythmogenic calcium waves depend on exceeding a threshold sarcoplasmic reticulum calcium content, which is modulated by ryanodine receptor properties.

Limitations

The exact mechanism of alternating axis in bidirectional VT remains unresolved.
The hypothesis that loss of RyR function predisposes to VF requires more experimental evidence.
Aspects of the mechanisms responsible for increased calcium leakage in heart failure remain controversial.

Cite This Study

Eisner et al. (2009) conducted a review in Cardiac Arrhythmias. Arrhythmogenic calcium waves require a threshold sarcoplasmic reticulum calcium content to be exceeded, a threshold that is decreased by increasing ryanodine receptor open probability.

synapsesocial.com/papers/6a1c824f0e2acd31eb2fd3df https://doi.org/10.1253/circj.cj-09-0478

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From the Ryanodine Receptor to Cardiac Arrhythmias

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

From the Ryanodine Receptor to Cardiac Arrhythmias

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Also Consider

Also Consider