Why the study?
Does chronic amiodarone treatment alter the magnitude or shape of the voltage dispersion curve and its relation to VF vulnerability in isolated rabbit hearts?
Population
Isolated rabbit hearts (n=16 total; 8 baseline conditions, 8 after chronic amiodarone treatment)
Comparison
Chronic amiodarone treatment vs Baseline conditions (no amiodarone)
Design
Preclinical
Authors
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Voltage dispersion timing correlates with VF vulnerability in rabbit hearts; leaves open clinical translation of amiodarone's rightward shift.
Does chronic amiodarone treatment alter the magnitude or shape of the voltage dispersion curve and its relation to VF vulnerability in isolated rabbit hearts?
Repolarization dispersion in the voltage domain closely correlates with VF vulnerability and is shifted rightward by amiodarone without changing magnitude, offering an alternate approach to evaluate repolarization heterogeneity.
Behrens et al. (1998) studied this question.
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