November 4, 1997Circulation
Evaluation of the Spatial Aspects of T-Wave Complexity in the Long-QT Syndrome
Why the study?
Does the index of complexity of repolarization (CR24h) derived from 24-hour 12-lead Holter recordings accurately identify patients with long-QT syndrome compared to controls?
Population
76 subjects, comprising 36 patients with long-QT syndrome (LQTS) and 40 control subjects.
Comparison
Calculation of the index of complexity of… vs Control subjects with normal repolarization.
Design
Case-control
Authors
Discussion
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Implication
May aid noninvasive LQTS identification on Holter; hypothesis-generating and requires prospective validation before clinical use.
Structured PICO
Does the index of complexity of repolarization (CR24h) derived from 24-hour 12-lead Holter recordings accurately identify patients with long-QT syndrome compared to controls?
P
Population
76 subjects, comprising 36 patients with long-QT syndrome (LQTS) and 40 control subjects.
I
Intervention
Calculation of the index of complexity of repolarization (CR24h) using principal component analysis applied to 24-hour, 12-lead Holter recordings.
C
Comparator
Control subjects with normal repolarization.
O
Outcome
Average 24-hour complexity of repolarization (CR24h) and its diagnostic accuracy for identifying LQTS.surrogate
The CR24h index derived from 12-lead Holter recordings provides an objective, quantitative measure of T-wave complexity that can help identify long-QT syndrome, even in symptomatic patients with normal QT intervals.
Cite This Study
Priori et al. (1997) studied this question.