Key result
Delaying direct angioplasty in AMI increases 30-day mortality risk ~60% per successive time interval.
Why the study?
Does the time delay to direct coronary angioplasty affect 30-day mortality in patients with acute myocardial infarction?
RCT (n=565)
Yes
Does the time delay to direct coronary angioplasty affect 30-day mortality in patients with acute myocardial infarction?
Effect estimate: OR 1.6
p-value: p=0.008
Time to treatment with direct coronary angioplasty is a critical determinant of 30-day mortality in acute myocardial infarction, with longer delays significantly increasing the risk of death.
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Delays to direct angioplasty were associated with higher 30-day AMI mortality; extends thrombolysis time-to-treatment data but leaves open need for randomized confirmation.
Berger et al. (1999) conducted an RCT in Acute myocardial infarction (n=565). Direct coronary angioplasty vs. Different time intervals to first balloon inflation was evaluated on 30-day mortality (OR 1.6, p=0.008). Delaying direct coronary angioplasty significantly increased 30-day mortality in acute myocardial infarction, with the odds of death increasing 1.6 times for each successive time interval (P=0.008).
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