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May 1, 1996Journal of Biological ChemistryOpen Access

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

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Population

293 cells transfected with the type 1A angiotensin II receptor (AT1A-R)

Comparison

Angiotensin II challenge, overexpression of GRK… vs Control cells

Design

Preclinical

Authors

MOMartin OppermannTransnational Press LondonNFNeil J. FreedmanDuke UniversityRAR. Wayne AlexanderGeneral / Preventive / Lipids

Discussion

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Implication

GRK-mediated AT1A-R phosphorylation supports receptor desensitization studies; leaves open relevance to cardiovascular signaling or therapy.

Structured PICO

P
Population
293 cells transfected with the type 1A angiotensin II receptor (AT1A-R)
I
Intervention
Angiotensin II challenge, overexpression of GRK mutants/wild-type, or PKC inhibitor staurosporine
C
Comparator
Control cells
O
Outcome
Receptor phosphorylation and desensitization (measured by phosphoinositide hydrolysis and GTPase activity)surrogate

Receptor phosphorylation by G protein-coupled receptor kinases plays a key role in the rapid agonist-induced desensitization of the type 1A angiotensin II receptor.

Cite This Study

Oppermann et al. (1996) studied this question.

synapsesocial.com/papers/6a1c8a060e2acd31eb2fdab7https://doi.org/10.1074/jbc.271.22.13266
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Also Consider

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  1. 1Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.1992 · 107 citations
  2. 2Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells1995 · 132 citations
  3. 3Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor.1994 · 191 citations
  4. 4Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.1990 · 404 citations
  5. 5Protein kinase C translocation in intact vascular smooth muscle strips1990 · 108 citations