Key result
Chronic fatigue syndrome is linked to ~3-fold higher residual torsion vs matched controls.
Population
12 female subjects with chronic fatigue syndrome diagnosed within 2 years fulfilling Fukuda criteria, and 10…
Design
Cross-sectional, Image analysis was performed blinded to the status of…
Authors
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May indicate subtle cardiac impairment in chronic fatigue syndrome; Level 4 case-control data leave open causality and clinical relevance.
Cross-Sectional (n=22)
Single-blind
No
Absolute Event Rate: 5.3% vs 1.7%
p-value: p=0.0001
Patients with chronic fatigue syndrome exhibit markedly reduced cardiac mass and blood pool volumes, resulting in significant impairments in stroke volume, cardiac output, and delayed release of myocardial torsion.
Hollingsworth et al. (2011) conducted a cross-sectional in Chronic fatigue syndrome (n=22). Chronic fatigue syndrome vs. Healthy matched controls was evaluated on Residual torsion at 150% of end-systolic time (p=0.0001). Patients with chronic fatigue syndrome had significantly higher residual torsion at 150% of end-systolic time compared to matched controls (5.3° vs 1.7°, P=0.0001), indicating delayed torsion release.
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