Key result
Greater myocardial extracellular expansion was associated with reduced circumferential shortening (B=-0.1; P=0.0001), lower LV end-diastolic volume index, and lower LV end-diastolic mass index.
Why the study?
Is myocardial extracellular expansion associated with left ventricular remodeling and mechanical dysfunction in a community-based multiethnic population?
Cohort (n=1,230)
Is myocardial extracellular expansion associated with left ventricular remodeling and mechanical dysfunction in a community-based multiethnic population?
Effect estimate: B=-0.1
p-value: p=0.0001
Greater myocardial extracellular expansion is associated with reduced LV volumes, mass, and subclinical mechanical dysfunction, with notable sex-specific differences in deformation patterns.
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Supports association of extracellular expansion with subclinical LV dysfunction in multiethnic adults; leaves open causal role and need for longitudinal validation.
Donekal et al. (2014) conducted a cohort in No history of previous cardiovascular events (n=1,230). Myocardial extracellular expansion (ECE) was evaluated on Circumferential shortening (B=-0.1, p=0.0001). Greater myocardial extracellular expansion was associated with reduced circumferential shortening (B=-0.1; P=0.0001), lower LV end-diastolic volume index, and lower LV end-diastolic mass index.
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