Why the study?
Does left atrial pressure clamping to produce nonfilling diastoles affect the rate of left ventricular pressure fall and reveal restoring forces in anesthetized open-chest dogs?
Population
Anesthetized open-chest dogs (n = 8)
Comparison
Left atrial pressure clamping during systole to… vs Preceding normal beats
Design
Preclinical
Authors
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Supports restoring forces at low LVEDP in dogs; leaves open translation to human diastolic assessment.
Does left atrial pressure clamping to produce nonfilling diastoles affect the rate of left ventricular pressure fall and reveal restoring forces in anesthetized open-chest dogs?
Restoring forces in the left ventricle are present at low physiological end-diastolic pressures but absent at high pressures, and filling retards the rate of fall of left ventricular pressure.
Bell et al. (1996) studied this question.
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