Key result
Dobutamine increased left ventricular restoring forces independently of changes in end-systolic volume, shifting the fully relaxed pressure-ESV relation by an average of -2.6 +/- 1.6 mmHg.
Why the study?
Does dobutamine increase left ventricular restoring forces independently of end-systolic volume in an open-chest dog model?
Population
Open-chest dogs with intact mitral valves (n=8 total; 6 for main experiments, 2 for additional experiments)
Comparison
Dobutamine vs Control
Design
Preclinical
Authors
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Findings from this open-chest dog model should not inform clinical dobutamine use; extends prior observations but leaves translation to human diastolic function open.
Does dobutamine increase left ventricular restoring forces independently of end-systolic volume in an open-chest dog model?
Effect estimate: Mean shift -2.6 mmHg
In an open-chest dog model, dobutamine increases left ventricular restoring forces independently of changes in end-systolic volume, an effect that may be partly related to increased coronary blood volume.
Bell et al. (1998) studied Left ventricular restoring forces in open-chest dogs (n=8). Dobutamine vs. Control was evaluated on Fully relaxed pressure (FRP) to end-systolic volume (ESV) relation (Mean shift -2.6 mmHg). Dobutamine increased left ventricular restoring forces independently of changes in end-systolic volume, shifting the fully relaxed pressure-ESV relation by an average of -2.6 +/- 1.6 mmHg.
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