January 14, 2005Journal of Cardiovascular Pharmacology
Effects of Dobutamine on Left Ventriculoarterial Coupling and Mechanical Efficiency in Acutely Ischemic Pigs
Key result
In acutely ischemic pigs, dobutamine infusion restored ventriculoarterial coupling but increased myocardial oxygen consumption and impaired mechanical efficiency.
Why the study?
Does dobutamine improve left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs?
Population
12 acutely ischemic pigs (left anterior descending coronary artery ligated)
Comparison
Dobutamine infusion (5 microg x kg x min)… vs No intervention (followed for 180 minutes)
Design
Preclinical, randomly divided into 2 groups
Follow-up
180 minutes
Authors
Discussion
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Implication
Dobutamine's efficiency costs in ischemia warrant caution; animal data leaves open human translation and efficiency-focused alternatives.
Study Design
Type
RCT (n=12)
Randomization
Randomized
Structured PICO
Does dobutamine improve left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs?
P
Population
12 acutely ischemic pigs subjected to left anterior descending coronary artery ligation, followed for 180 minutes.
I
Intervention
Dobutamine infusion (5 microg x kg(-1) x min(-1)) starting after T60 measures
C
Comparator
No intervention (followed for 180 minutes)
O
Outcome
Left ventriculoarterial (VA) coupling and mechanical efficiencysurrogate
In an acute ischemic pig model, dobutamine restored ventriculoarterial coupling but increased myocardial oxygen consumption and impaired mechanical efficiency.
Cite This Study
Kolh et al. (2005) conducted an RCT in Acute ischemia (n=12). Dobutamine vs. No intervention (CTRL group) was evaluated on Left ventriculoarterial coupling and mechanical efficiency. In acutely ischemic pigs, dobutamine infusion restored ventriculoarterial coupling but increased myocardial oxygen consumption and impaired mechanical efficiency.