Key result
Metabolic syndrome significantly increased the risk of developing paroxysmal atrial fibrillation and/or atrial flutter (OR 2.8) in patients without structural heart diseases.
Why the study?
Does metabolic syndrome increase the risk of paroxysmal atrial fibrillation and/or atrial flutter in hospitalized patients without structural heart disease?
Population
592 consecutive hospitalized patients without obvious structural heart diseases, with sinus rhythm confirmed…
Comparison
Metabolic syndrome vs Absence of metabolic syndrome
Design
Cohort
Authors
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Metabolic syndrome may elevate paroxysmal AF risk; hypothesis-generating for targeted interventions, with prospective trials needed before practice change.
Cohort (n=592)
No
Does metabolic syndrome increase the risk of paroxysmal atrial fibrillation and/or atrial flutter in hospitalized patients without structural heart disease?
Effect estimate: OR 2.8 (95% CI 1.3-6.2)
Absolute Event Rate: 9% vs 4%
p-value: p=<0.01
Metabolic syndrome, particularly driven by obesity (BMI ≥25 kg/m2), is independently associated with a nearly 3-fold increased risk of paroxysmal atrial fibrillation or flutter in patients without structural heart disease.
Umetani et al. (2007) conducted a cohort in Metabolic syndrome (n=592). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Incidence of paroxysmal atrial fibrillation (PAF) and/or atrial flutter (PAFL) (OR 2.8, 95% CI 1.3-6.2, p=<0.01). Metabolic syndrome significantly increased the risk of developing paroxysmal atrial fibrillation and/or atrial flutter (OR 2.8) in patients without structural heart diseases.
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