The Proliferative Changes of Renal Afferent Arteriolar Walls and Renin-Angiotensin-Aldosterone System Inhibitors

The hyperfiltration theory of Brenner et al. in 1982, is widely recognized and studied closely as a final common pathway of kidney function deterioration from some point to the irreversible end-stage by any first kidney insult. In the paper, the deterioration of kidney function is induced because of the glomerular hemodynamics, glomerular hyperfiltration, and glomerular hypertension.