Why the study?
Prosthetic valve thrombosis is a rare condition with limited treatment options.
Does a modified alteplase regimen (10 mg bolus plus 90 mg infusion over 20 hours) with heparin improve mechanical aortic valve thrombosis in a high-risk surgical patient?
Case Report (n=1)
Does a modified alteplase regimen (10 mg bolus plus 90 mg infusion over 20 hours) with heparin improve mechanical aortic valve thrombosis in a high-risk surgical patient?
A modified fibrinolytic regimen of alteplase 10 mg bolus and 90 mg infusion over 20 hours with heparin successfully treated mechanical aortic valve thrombosis in a high-risk surgical patient without bleeding complications.
May support modified alteplase-heparin regimen in select mechanical aortic valve thrombosis cases; leaves open need for prospective validation.
Prosthetic valve thrombosis is a rare phenomenon with limited treatment options. Current management choices include anticoagulation with or without fibrinolysis or surgical valve replacement for appropriate candidates. We report an alternative fibrinolytic and anticoagulation regimen resulting in successful treatment of a patient presenting with mechanical aortic valve thrombosis.
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Mustafa et al. (2021) conducted a case report in Mechanical aortic valve thrombosis (n=1). Alteplase and heparin was evaluated on Restoration of mechanical aortic valve function.
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