Why the study?
While surgery is standard for prosthetic valve thrombosis, thrombolysis has emerged as an alternative in patients with high surgical risk or surgical refusal.
Does intravenous thrombolysis with tenecteplase improve valve function and clinical status in a patient with obstructive prosthetic valve thrombosis?
Population
One 38-year-old woman with obstructive aortic mechanical prosthetic thrombosis and embolic STEMI refusing surgery
Design
Case report
Key result
Intravenous thrombolysis with tenecteplase successfully restored prosthetic valve function and reduced the transvalvular gradient from 56 to 23 mmHg in a patient with obstructive aortic prosthetic thrombosis.
Authors
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Thrombolysis offers a viable option for prosthetic valve thrombosis patients refusing surgery; extends RCT evidence to high-risk nonsurgical candidates.
Case Report (n=1)
Does intravenous thrombolysis with tenecteplase improve valve function and clinical status in a patient with obstructive prosthetic valve thrombosis?
Thrombolysis with tenecteplase is a feasible and effective alternative to surgery for obstructive prosthetic valve thrombosis in selected patients, even when complicated by embolic STEMI.
Lebbar et al. (2025) conducted a case report in Prosthetic valve thrombosis (n=1). Tenecteplase was evaluated on Transvalvular gradient reduction and restoration of valve mobility. Intravenous thrombolysis with tenecteplase successfully restored prosthetic valve function and reduced the transvalvular gradient from 56 to 23 mmHg in a patient with obstructive aortic prosthetic thrombosis.