Why the study?
Does tissue plasminogen activator resolve thrombus and improve gradients in a patient with prosthetic mitral valve thrombosis?
Does tissue plasminogen activator resolve thrombus and improve gradients in a patient with prosthetic mitral valve thrombosis?
Thrombolytic therapy with tPA successfully resolved prosthetic mitral valve thrombosis without complications in a patient who refused surgery.
May offer nonsurgical option for prosthetic mitral valve thrombosis in select patients; hypothesis-generating and should not yet change practice.
Prosthetic heart valve thrombosis is a rare but serious complication. Surgery is the first-line therapy in symptomatic obstructive mechanical valve thrombosis, thrombolytic therapy has been used as an alternative to surgical treatment. In this case report we described a 47-year-old woman who had undergone coronary artery bypass graft and mitral valve replacement operation 9 months ago. A thrombus was detected on the prosthetic mitral valve with high transmitral gradient by transoesophageal echocardiography. Tissue plasminogen activator treatment was administered successfully. The gradient was improved on prosthetic mitral valve and embolic complications or bleeding were not occurred.
No takes yet. Share an insight, caveat, or question.
Gazı et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: