Key result
Thrombolytic therapy with the plasminogen activator urokinase resulted in complete resolution of the prosthetic mitral valve thrombus in a 61-year-old female patient.
Case Report (n=1)
No
Thrombolytic therapy with urokinase successfully resolved a prosthetic mitral valve thrombosis in a patient presenting with a TIA and subtherapeutic anticoagulation.
Suggests potential role for urokinase thrombolysis in prosthetic valve thrombosis; leaves open need for controlled trials before wider adoption.
Prosthetic valve thrombosis is one of the most severe complications after surgical valve replacement. There are many possible presentations: from asymptomatic to life-threatening complications. We report on a 61-year-old female patient with prosthetic replacement of the aortic and mitral valve in the in-house department of cardiac surgery 3 months ago. The patient was suffering from aphasia during 5 minutes in domesticity. After her presentation in the emergency room, the echocardiographic examination revealed a thrombotic formation of the prosthetic mitral valve. At presentation, the anticoagulation was outside the effective range (INR: 1.7). A successful thrombolytic therapy with the plasminogen activator urokinase was begun with complete resolution of the thrombus.
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Koban et al. (2016) conducted a case report in Prosthetic mitral valve thrombosis (n=1). Thrombolytic therapy with urokinase was evaluated on Resolution of the thrombus. Thrombolytic therapy with the plasminogen activator urokinase resulted in complete resolution of the prosthetic mitral valve thrombus in a 61-year-old female patient.
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