Why the study?
Does redo surgery reduce complications compared to thrombolysis in patients with obstructive prosthetic valve thrombosis?
Population
80 patients (85 episodes) with prosthetic valve thrombosis (PVT), mean age 49.4, 40% male.
Comparison
Redo surgery vs Thrombolysis (streptokinase)
Design
Cohort
Follow-up
in-hospital
Key result
Surgery was associated with significantly fewer total complications compared to thrombolysis in patients with obstructive prosthetic valve thrombosis (14.2% vs. 68.7%, P<0.001).
Authors
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May favor surgery over thrombolysis for obstructive prosthetic valve thrombosis; leaves open need for randomized confirmation.
Cohort (n=80)
No
Does redo surgery reduce complications compared to thrombolysis in patients with obstructive prosthetic valve thrombosis?
Absolute Event Rate: 14.2% vs 68.7%
p-value: p=< 0.001
In patients with obstructive prosthetic valve thrombosis, surgery is associated with significantly fewer complications and higher success rates compared to thrombolysis.
Separham et al. (2015) conducted a cohort in Prosthetic valve thrombosis (n=80). Surgery vs. Thrombolysis was evaluated on Total complications (p=< 0.001). Surgery was associated with significantly fewer total complications compared to thrombolysis in patients with obstructive prosthetic valve thrombosis (14.2% vs. 68.7%, P<0.001).
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