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March 10, 2001Swiss Medical WeeklyOpen Access

Treatment-related emboli occurred in 5 patients (29%) and 5 patients died (mortality 29%) within 30 days.

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Population

17 patients with symptomatic mechanical prosthetic heart valve thrombosis (PVT), mean age 55 +/- 15 years.

Design

Case_series

Follow-up

28 +/- 28 months

Authors

LBLaurent A. BollagALA. Z LINKAPDPaul Dubach

Discussion

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Overview

High short-term mortality in symptomatic mechanical PVT despite treatment warrants vigilant anticoagulation; leaves open optimal strategy in larger studies.

Key Points

  • To analyze the complications and outcomes of treatment for patients with mechanical prosthetic heart valve thrombosis.
  • Reviewed clinical and echocardiographic findings of 17 patients with symptomatic mechanical PVT
  • Analyzed complications and outcomes related to surgery and/or thrombolysis
  • Conducted prospective follow-up after treatment
  • Symptomatic PVT occurred a mean of 8.4 years post valve replacement, with 29% mortality within 30 days.
  • The most common cause of PVT was inadequate anticoagulation (65%), with haemodynamic obstruction present in 88%.
  • Treatment included surgery for 71% and thrombolysis for 18%, with a long-term unremarkable follow-up in survivors.

Structured PICO

P
Population
17 patients with symptomatic mechanical prosthetic heart valve thrombosis (PVT), mean age 55 +/- 15 years.
I
Intervention
Treatment for PVT including primary reoperation (n=12), thrombolysis with urokinase (n=3), or reinstitution of adequate anticoagulation (n=1).
O
Outcome
Complications and outcome of surgery and/or thrombolysis (including mortality and treatment-related emboli)hard clinical

Mechanical prosthetic valve thrombosis carries a high morbidity and mortality (29% 30-day mortality) despite aggressive treatment, though long-term prognosis for survivors is excellent.

Cite This Study

Bollag et al. (2001) studied this question.

synapsesocial.com/papers/6a6f34cb35aa2c282ce09c66https://doi.org/10.4414/smw.2001.09685
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prosthetic Valve Thrombosis2015 · 25 citations
  2. 2Retrospective Analysis of Therapeutic Modalities in Prosthetic Heart Valve Thrombosis: A 15-Year Single-Center Experience2025
  3. 3Surgical Treatment of Left-sided Prosthetic Valve Thrombosis: Short and Long-term Results2005 · 15 citations
  4. 4Treatment of Prosthetic Valve Thrombosis: Current Evidence and Future Directions2015 · 40 citations
  5. 5Thrombolysis in Prosthetic Valve Thrombosis: A Safe and Effective Alternative?2025