Population
Eucaryotic cell-free translation systems and in vivo models evaluating CAT and preproinsulin genes
Comparison
Mutations in the context sequences flanking AUG… vs Optimal vs suboptimal context sequences, AUG vs…
Design
Preclinical
Authors
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No immediate clinical application; leaves open non-AUG roles in human disease models.
In eucaryotic translation systems, initiation fidelity mimics in vivo conditions, with downstream hairpin structures enhancing suboptimal AUG recognition and non-AUG codons like GUG functioning at only 3-5% the efficiency of AUG.
Marilyn Kozak (1989) studied this question.
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