Key result
Prolonged exposure (>1 h) to atrial natriuretic peptide reduced natriuretic peptide receptor-A concentrations in a time-dependent manner, with a half-life of ~8 h in primary cells.
Population
Cultured cell lines including primary bovine aortic endothelial cells, immortalized HeLa cells, and 293T…
Comparison
Atrial natriuretic peptide exposure for varying… vs Unexposed cells or shorter exposure times
Design
Preclinical
Follow-up
up to 24 hours
Authors
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May constrain sustained ANP effects; leaves open in vivo relevance for HF therapies.
Prolonged exposure to atrial natriuretic peptide induces time-dependent degradation of its receptor, NPR-A, demonstrating that down-regulation is a universal but relatively slow property that varies by cell type.
Flora et al. (2010) studied this question. Atrial Natriuretic Peptide (ANP) was evaluated on Cellular NPR-A levels. Prolonged exposure (>1 h) to atrial natriuretic peptide reduced natriuretic peptide receptor-A concentrations in a time-dependent manner, with a half-life of ~8 h in primary cells.