Atrial Natriuretic Peptide Suppresses the Transcription of Its Guanylyl Cyclase-linked Receptor

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Population

Rat aortic smooth muscle cells

Design

Preclinical

Authors

Discussion

Does not alter clinical practice; leaves open relevance of ANP autoregulation to human vascular disease.

Population

Rat aortic smooth muscle cells

Intervention

Atrial natriuretic peptide (ANP) treatment

Outcome

NPR-A and NPR-C receptor populations, mRNA levels, and gene promoter activitysurrogate

ANP autoregulates its own receptors in rat aortic smooth muscle cells by suppressing NPR-A gene expression through a cGMP-dependent element.

Cao et al. (1995) studied this question.

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