Proper glycosylation and phosphorylation of the type A natriuretic peptide receptor are required for hormone-stimulated guanylyl cyclase activity.
Population
COS cells expressing natriuretic peptide receptor type A (NPR-A)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Post-translational modifications essential for NPR-A activity; leaves open their modulation as a therapeutic target in cardiovascular disease.
Structured PICO
P
Population
COS cells expressing natriuretic peptide receptor type A (NPR-A)
I
Intervention
Site-specific mutations in the kinase homology domain of NPR-A
O
Outcome
Hormone-stimulated guanylyl cyclase activitysurrogate
Proper glycosylation and phosphorylation of the NPR-A receptor are essential for its hormone-stimulated guanylyl cyclase activity.
Cite This Study
Koller et al. (1993) studied this question.