Key result
Exposure of NPR-B to C-type natriuretic peptide resulted in time-dependent dephosphorylation and desensitization of the receptor, indicating catalytic activity is coupled to phosphorylation state.
The catalytic activity of the natriuretic peptide receptor B is tightly coupled to its phosphorylation state, with dephosphorylation acting as a key mechanism of desensitization.
No takes yet. Share an insight, caveat, or question.
In vitro NPR-B phosphorylation data; leaves open CNP signaling relevance in cardiovascular disease.
Lincoln R. Potter (1998) studied this question. C-type natriuretic peptide (CNP) was evaluated on NPR-B receptor dephosphorylation and desensitization. Exposure of NPR-B to C-type natriuretic peptide resulted in time-dependent dephosphorylation and desensitization of the receptor, indicating catalytic activity is coupled to phosphorylation state.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: