Why the study?
Does nitroaspirin plus clopidogrel reduce platelet thromboembolism and intimal thickening with less bleeding compared to aspirin plus clopidogrel in mice?
Population
Mice in models of collagen plus epinephrine-induced pulmonary thromboembolism, tail transection bleeding…
Comparison
Nitroaspirin plus clopidogrel administered… vs Aspirin plus clopidogrel administered orally for…
Design
Preclinical
Follow-up
5 days
Authors
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Hypothesis-generating in murine thromboembolism models; leaves open clinical translation of nitroaspirin-clopidogrel combinations.
Does nitroaspirin plus clopidogrel reduce platelet thromboembolism and intimal thickening with less bleeding compared to aspirin plus clopidogrel in mice?
In mice, nitroaspirin plus clopidogrel provides superior antithrombotic efficacy, reduces intimal thickening, and causes less bleeding than aspirin plus clopidogrel.
Momi et al. (2005) studied this question.
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