January 1, 1999Thrombosis and Haemostasis

Endogenous Nitric Oxide Acts as a Natural Antithrombotic Agent In Vivo by Inhibiting Platelet Aggregation in the Pulmonary Vasculature

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Population

Rabbit and mouse models of pulmonary platelet thromboembolism induced by intravenous collagen plus epinephrine

Comparison

L-NAME and L-arginine vs Phenylephrine and nicardipine

Design

Preclinical

Authors

MEMichael EmersonUniversity of North Carolina at Chapel Hill SMStefania MomiUniversity of Perugia WPWilliam PaulUniversity of London

Discussion

Member takes

Implication

Endogenous NO limits pulmonary platelet accumulation in animals; hypothesis-generating for human thrombosis and requires clinical validation.

Structured PICO

Population

Rabbit and mouse models of pulmonary platelet thromboembolism induced by intravenous collagen plus epinephrine

Intervention

L-NAME (nitric oxide synthase inhibitor) and L-arginine (nitric oxide synthase substrate)

Comparator

Phenylephrine and nicardipine (used to rule out hemodynamic effects)

Outcome

Accumulation of 111In-labelled platelets in the pulmonary vasculature (rabbits); thromboembolic mortality, fall in circulating platelets, and percentage of pulmonary vessels occluded by platelet thrombi (mice)surrogate

Endogenous nitric oxide functions as a natural antithrombotic agent in vivo by directly inhibiting platelet aggregation in the pulmonary vasculature, independent of hemodynamic changes.

Cite This Study

Emerson et al. (1999) studied this question.

synapsesocial.com/papers/6a7f2901b5ccfbbe2d84eac4 https://doi.org/10.1055/s-0037-1614607

Topics

Pulmonary embolism

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Implication

Endogenous NO limits pulmonary platelet accumulation in animals; hypothesis-generating for human thrombosis and requires clinical validation.

Endogenous Nitric Oxide Acts as a Natural Antithrombotic Agent In Vivo by Inhibiting Platelet Aggregation in the Pulmonary Vasculature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endogenous Nitric Oxide Acts as a Natural Antithrombotic Agent In Vivo by Inhibiting Platelet Aggregation in the Pulmonary Vasculature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider