January 1, 2001Arteriosclerosis Thrombosis and Vascular Biology

Endogenous Nitric Oxide and Prostaglandins Synergistically Counteract Thromboembolism in Arterioles but Not in Venules

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Population

Rabbit mesenteric arterioles and venules in an in vivo model of thromboembolism induced by micropipette…

Comparison

Combined inhibition of NO synthase… vs Control, L-NA alone, or ASA alone

Design

Preclinical

Authors

MBMartijn A. W. BroedersRijnland Ziekenhuis GTGeert-Jan TangelderAmsterdam UMC Location Vrije Universiteit Amsterdam DSDick W. SlaafUniversity of Louisville

Discussion

Member takes

Implication

Endogenous NO and prostaglandins synergistically limit arteriolar thromboembolism in this model; human studies required before considering therapeutic implications.

Structured PICO

Population

Rabbit mesenteric arterioles and venules (diameter 18 to 40 micrometer) in an in vivo model of thromboembolism induced by micropipette puncture

Intervention

Combined inhibition of NO synthase (N(G)-nitro-L-arginine [L-NA] 0.1 mmol/L; local superfusion) and of cyclooxygenase (aspirin [ASA] 100 mg/kg IV)

Comparator

Control, L-NA alone, or ASA alone

Outcome

Embolization durationsurrogate

Endogenous NO and prostaglandins synergistically counteract ongoing thromboembolism after vessel wall injury in arterioles, but not in venules.

Cite This Study

Broeders et al. (2001) studied this question.

synapsesocial.com/papers/6a906de5fdaee66aea840d6d https://doi.org/10.1161/01.atv.21.1.163

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Implication

Endogenous NO and prostaglandins synergistically limit arteriolar thromboembolism in this model; human studies required before considering therapeutic implications.