Why the study?
Does a nitric oxide-releasing aspirin derivative reduce restenosis compared to aspirin in hypercholesterolemic mice undergoing balloon angioplasty?
Population
Low-density lipoprotein receptor-deficient mice undergoing balloon angioplasty
Comparison
Nitric oxide-releasing aspirin derivative… vs Aspirin
Design
Preclinical
Authors
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May reduce restenosis in hypercholesterolemic models; leaves open translation to human angioplasty outcomes.
Does a nitric oxide-releasing aspirin derivative reduce restenosis compared to aspirin in hypercholesterolemic mice undergoing balloon angioplasty?
A nitric oxide-releasing aspirin derivative (NCX-4016) effectively reduces restenosis after balloon angioplasty in a hypercholesterolemic mouse model, suggesting potential therapeutic value.
Napoli et al. (2001) studied this question.
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