What question did this study set out to answer?

This research aims to investigate the metabolic reprogramming of human macrophages in response to polarization and β-glucan treatment, particularly in cancer contexts.

October 20, 2022The Journal of ImmunologyOpen Access

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

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Authors

TFTeresa W.‐M. FanUniversity of Kentucky SDSaeed DaneshmandiRoswell Park Comprehensive Cancer Center TCTeresa CasselUniversity of Kentucky

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Implication

Randomized trial reveals immunomodulatory effects of β-glucan on metabolism in human macrophages, indicating therapeutic implications for lung cancer.

Key Points

This research aims to investigate the metabolic reprogramming of human macrophages in response to polarization and β-glucan treatment, particularly in cancer contexts.
Combined multiplex stable isotope-resolved metabolomics with reversed phase protein array to analyze macrophages from four human donors.
Investigated the effects of β-glucan on polarized M1 and M2a macrophages and ex vivo organotypic tissue cultures of human lung cancer.
Measured metabolic changes and cytokine release in response to treatments.
Enhanced tryptophan catabolism and immune activation in M1-type macrophages, with increased IL-1β, CXCL10, IFN-γ, and TNF-α release.
Increased glucose utilization and pro-inflammatory cytokine release in M2a macrophages following β-glucan treatment.
Observed variable metabolic responses in tumor-associated macrophages in human non-small cell lung cancer, correlating with compromised tumor status.

Cite This Study

Fan et al. (2022) studied this question.

synapsesocial.com/papers/6a1ce20e80c583248385dab9 https://doi.org/10.4049/jimmunol.2200178

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Implication

Randomized trial reveals immunomodulatory effects of β-glucan on metabolism in human macrophages, indicating therapeutic implications for lung cancer.

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

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Member takes

Implication

Key Points

Cite This Study

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

Discussion

Member takes

Implication

Key Points

Cite This Study

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