What question did this study set out to answer?

To determine how yeast-derived whole beta-glucan particles reprogram macrophage phenotypes and evaluate their role in modulating natural killer cell antitumor responses.

July 17, 2023Clinical & Experimental ImmunologyOpen Access

Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer

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Authors

ZZZhichao ZhuNanjing Tech University LHLiuyang HeNanjing Traditional Chinese Medicine Hospital YBYu BaiKunming Medical University

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Implication

Experimental study demonstrates delayed tumor growth via macrophage reprogramming and natural killer cell activation in mice, indicating a potent immunotherapy mechanism.

Key Points

To determine how yeast-derived whole beta-glucan particles reprogram macrophage phenotypes and evaluate their role in modulating natural killer cell antitumor responses.
Examined in vitro differentiation and phenotype conversion of M0, M2, and tumor-associated macrophages into M1 macrophages upon whole beta-glucan particle (WGP) exposure.
Evaluated the role of the extracellular regulated protein kinase (ERK) signaling pathway and measured downstream natural killer (NK) cell activation and cytotoxicity in vitro.
Assessed in vivo tumor growth, immune cell infiltration, and the necessity of NK cells via NK-cell depletion in tumor-bearing mice treated with oral WGP.
WGP induced M0, M2, and tumor-associated macrophages to polarize into an antitumor M1 phenotype via ERK pathway signaling.
WGP-treated macrophages elevated activating receptor expression and enhanced cytotoxic activity in NK cells in vitro.
Oral administration of WGP delayed tumor growth and expanded macrophage and NK-cell populations in mice, whereas NK-cell depletion substantially reduced antitumor efficacy.

Cite This Study

Zhu et al. (2023) studied this question.

synapsesocial.com/papers/6a9e2604e056b05edee98398 https://doi.org/10.1093/cei/uxad080

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Implication

Experimental study demonstrates delayed tumor growth via macrophage reprogramming and natural killer cell activation in mice, indicating a potent immunotherapy mechanism.

Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Yeast β-glucan modulates macrophages and improves antitumor NK-cell responses in cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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