Why the study?
Does chronic sinoaortic denervation alter the mechanical properties and composition of the abdominal aorta in Wistar rats?
Population
16-week-old Wistar rats (n=16)
Comparison
Chronic sinoaortic denervation vs Sham-operated rats (n=8)
Design
Preclinical
Follow-up
6 weeks
Authors
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Rat findings should not alter practice; leaves open baroreflex role in human aortic remodeling.
Does chronic sinoaortic denervation alter the mechanical properties and composition of the abdominal aorta in Wistar rats?
Chronic sinoaortic denervation in rats reduces aortic distensibility and increases aortic wall cross-sectional area and collagen content, indicating the importance of intact arterial baroreceptors for large artery structure and function.
Lacolley et al. (1995) studied this question.
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