Why the study?
Does isoproterenol-induced hypertrophy alter left ventricular mechanical work and energetics in blood-perfused rat hearts?
Population
Cross-circulated (blood-perfused) rat heart preparation
Comparison
Isoproterenol 1.2 mg/kg/day for 3 days or 7 days vs Saline 24 microl/day for 3 and 7 days (Sa)
Design
Preclinical
Follow-up
3 or 7 days
Authors
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Impaired relaxation at high rates may favor rate control in hypertrophy; leaves open translation of energetics findings to clinical phenotypes.
Does isoproterenol-induced hypertrophy alter left ventricular mechanical work and energetics in blood-perfused rat hearts?
In isoproterenol-induced hypertrophied rat hearts, lowering heart rate may improve mechanical work and energetics despite impaired LV relaxation and decreased expression of key calcium-handling proteins.
Nakajima‐Takenaka et al. (2009) studied this question.
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