Why the study?
Does chronic isoproterenol infusion alter the expression of hypertrophy-associated genes in male Wistar rats?
Population
Male Wistar rats
Comparison
Isoproterenol 2.4 mg/kg/day via subcutaneously… vs Propranolol 9.9 mg/kg/day, both isoproterenol…
Design
Preclinical
Follow-up
Up to 3 days
Authors
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Validates isoproterenol as a rodent hypertrophy model; leaves open translation to human cardiac remodeling.
Does chronic isoproterenol infusion alter the expression of hypertrophy-associated genes in male Wistar rats?
Chronic isoproterenol infusion in rats induces cardiac hypertrophy and alters gene expression in a pattern consistent with pressure overload hypertrophy.
Boluyt et al. (1995) studied this question.
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