May 6, 2003HypertensionOpen Access

Regression of Isoproterenol-Induced Cardiac Hypertrophy by Na + /H + Exchanger Inhibition

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Why the study?

Does Na+/H+ exchanger inhibition prevent isoproterenol-induced cardiac hypertrophy and fibrosis in male Wistar rats?

Population

Male Wistar rats

Comparison

Isoproterenol combined with BIIB723, a selective… vs Isoproterenol alone and sex- and age-matched…

Design

Preclinical

Follow-up

30 days

Authors

Discussion

No immediate clinical implications; leaves open whether NHE inhibition prevents human cardiac hypertrophy.

Does Na+/H+ exchanger inhibition prevent isoproterenol-induced cardiac hypertrophy and fibrosis in male Wistar rats?

Population

Male Wistar rats

Intervention

Isoproterenol (5 mg/kg IP once daily) combined with BIIB723 (3 mg/kg/day), a selective inhibitor of the Na+/H+ exchanger, for 30 days

Comparator

Isoproterenol alone (5 mg/kg IP once daily) and sex- and age-matched rats receiving 0.9% saline IP daily (controls)

Outcome

Development of cardiac hypertrophy (assessed by left ventricular mass and heart weight-to-body weight ratio)surrogate

Inhibition of the Na+/H+ exchanger with BIIB723 prevents the development of isoproterenol-induced cardiac hypertrophy and fibrosis in a rat model.

Ennis et al. (2003) studied this question.

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