Why the study?
CT-PA is frequently used to evaluate suspected PE even in radiosensitive patients, prompting evaluation of reduced z-axis coverage to decrease radiation dose while preserving diagnostic sensitivity.
Does CT-PA with a reduced scan range maintain sensitivity for detecting pulmonary embolism while reducing radiation dose compared to standard full-lung CT-PA?
Does CT-PA with a reduced scan range maintain sensitivity for detecting pulmonary embolism while reducing radiation dose compared to standard full-lung CT-PA?
A reduced scan length in CT-PA substantially decreases radiation dose by nearly half while maintaining excellent diagnostic accuracy for detecting pulmonary embolism.
May reduce radiation in CT-PA for PE; hypothesis-generating and requires prospective confirmation before practice change.
PURPOSE: Computed tomography pulmonary angiography (CT-PA) is frequently used in the diagnostic workup of pulmonary embolism (PE), even in highly radiosensitive patient populations. This study aims to assess CT-PA with reduced z -axis coverage (compared with a standard scan range covering the entire lung) for its sensitivity for detecting PE and its potential to reduce the radiation dose. MATERIALS AND METHODS: We retrospectively analyzed 602 consecutive CT-PA scans with definite or possible PE reported. A reduced scan range was defined based on the topogram, where the cranial slice was set at the top of the aortic arch and the caudal slice at the top of the lower hemidiaphragm. Locations of emboli in relation to the reduced scan range were recorded. RESULTS: We included 513 CT-PA scans with definite acute PE in statistical analysis. Patients' median age was 66 (52 to 77) years, 46% were female. Median dose length product was 270.8 (111.3 to 503.9) mGy*cm. Comparing the original and reduced scan ranges, the mean scan length was significantly reduced by 48.0±8.6% (26.8±3.0 vs. 13.9±2.6 cm, P <0.001). Single emboli outside the reduced range in addition to emboli within were found in 15 scans (2.9%), while only 1 scan (0.2%) had an embolus outside the reduced range and none within it. The resulting sensitivity of CT-PA with reduced scan range was 99.81% (95% confidence interval: 98.74%-99.99%) for detecting any PE. CONCLUSION: A reduced scan length in CT-PA, as defined above, would substantially decrease radiation dose while maintaining diagnostic accuracy for detecting PE.
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Schmid et al. (2022) studied this question.
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