Why the study?
Does dose reduction in CT pulmonary angiography maintain diagnostic accuracy for detecting pulmonary embolism in a porcine model?
Population
6 anesthetized pigs with induced pulmonary embolism
Comparison
64-detector-row CT pulmonary angiography at 3… vs High-dose CTPA serving as a reference standard
Design
Preclinical, Images evaluated by 2 radiologists independently
Key result
A low-dose CTPA protocol (120 kV/80 mAseff.) maintained diagnostic accuracy for pulmonary embolism, while an ultra-low-dose protocol (80 kV/80 mAseff.) significantly impaired detection (P<0.05).
Authors
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Low-dose CTPA merits clinical testing; animal data leave optimal protocols unresolved for human use.
Does dose reduction in CT pulmonary angiography maintain diagnostic accuracy for detecting pulmonary embolism in a porcine model?
p-value: p=<0.05
Low-dose CTPA (120 kV/80 mAseff) maintains high diagnostic accuracy for pulmonary embolism detection, but ultra-low-dose (80 kV) impairs detection of smaller emboli.
Henes et al. (2011) studied Pulmonary embolism (n=6). Low-dose and ultra-low-dose CTPA protocols vs. Standard protocol (120 kV/120 mAseff.) and high-dose reference (120 kV/250 mAseff.) was evaluated on Detection rate of segmental and subsegmental pulmonary embolism (p=<0.05). A low-dose CTPA protocol (120 kV/80 mAseff.) maintained diagnostic accuracy for pulmonary embolism, while an ultra-low-dose protocol (80 kV/80 mAseff.) significantly impaired detection (P<0.05).