Population
PBMCs from 6 healthy anonymous adult donors and EV71-positive HFMD patients
Comparison
In vitro stimulation with 37 predicted EV71 CD4+… vs Scrambled peptide SP4 and DMSO (negative controls)
Design
Preclinical
Authors
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May guide T cell-targeted HFMD vaccine design; leaves open protective efficacy in patients.
Identification of a highly conserved, dominant CD4+ T cell epitope (A3) in EV71 suggests that prior exposure to other enteroviruses or poliovirus vaccination may modulate the immune response to EV71 infection.
Wei et al. (2012) studied this question.
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