Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 3, 1978Science

Platelet Factor 4: An Inhibitor of Collagenase

View Full Paper
Ask AI
Bookmark
Share

Population

In vitro assay systems using collagenase derived from cultured human skin and extracted from human…

Design

Preclinical

Authors

JHJudith Hiti-HarperHWHerbert WohlEHElvin Harper

Discussion

Loading...

Member takes

Overview

May modulate extracellular matrix turnover; leaves open any role in human fibrosis or remodeling.

Structured PICO

P
Population
In vitro assay systems using collagenase derived from cultured human skin and extracted from human granulocytes
I
Intervention
Human platelet factor 4 (PF4) with or without heparin
O
Outcome
Inhibition of collagenase activitysurrogate

Human platelet factor 4 acts as an inhibitor of collagenase, an effect that is independent of its heparin-neutralizing properties.

Cite This Study

Hiti-Harper et al. (1978) studied this question.

synapsesocial.com/papers/6a1d161c102421609404d3eahttps://doi.org/10.1126/science.203038
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of platelet factor 4 by adenosine diphosphate and other platelet-aggregating agents.1968 · 49 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,663 citations
  3. 3Human Granulocyte Collagenase1968 · 330 citations
  4. 4The rapid induction by phytohemagglutinin of increased α-aminoisobutyric acid uptake by lymphocytes1971 · 223 citations
  5. 5Tadpole Collagenase. Preparation and Purification<sup>*</sup>1966 · 394 citations