Why the study?
Does intravenous heparin affect PF4 release and platelet aggregation after aspirin administration?
Design
Other
Authors
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May promote platelet activation despite aspirin; leaves open clinical relevance of heparin-induced PF4 release.
Does intravenous heparin affect PF4 release and platelet aggregation after aspirin administration?
Heparin induces PF4 release and potentiates platelet aggregation despite aspirin-induced platelet blockade, highlighting a potential mechanism for heparin-induced platelet activation.
Cella et al. (1980) studied this question.
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