What does this research mean for the field?

Acetylcholine induces endothelium-dependent vasodilatation in the coronary circulation by stimulating the release of nitric oxide, which is rapidly converted to nitrite and nitrate. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1988British Journal of PharmacologyOpen Access

Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator

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Population

Isolated Langendorff-perfused heart of the rabbit

Design

Preclinical

Authors

JAJ.L. AmezcuaCentro Médico Nacional La Raza GDG. J. DustingFlorey Institute of Neuroscience and Mental Health RPRichard PalmerWelsh Ambulance Services NHS Trust

Discussion

Member takes

Implication

Does not alter clinical practice; leaves open translation of acetylcholine-NO coronary vasodilation to human endothelial function.

Structured PICO

Population

Isolated Langendorff-perfused heart of the rabbit

Intervention

Acetylcholine (0.03-3.0 microM) and exogenous nitric oxide (0.045-4.5 nmol)

Outcome

Vasodilatation and release of nitric oxide (measured by chemiluminescent signal)surrogate

Acetylcholine induces endothelium-dependent vasodilatation in the coronary circulation through the release of nitric oxide.

Cite This Study

Amezcua et al. (1988) studied this question.

synapsesocial.com/papers/6a1d180d73c56dd1bd2f281e https://doi.org/10.1111/j.1476-5381.1988.tb11711.x

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Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider