What does this research mean for the field?

Electrical excitation in the ventricle spreads rapidly along the endocardium followed by a slower syncytial spread through the wall, with no evidence of spread through individual cardiac muscle bundles. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To determine the pathway, speed, and spatial distribution of electrical impulse conduction through the ventricular wall.

November 1, 1953Circulation ResearchOpen Access

Spread of Electrical Activity Through the Wall of the Ventricle

View Full Paper

Ask AI

Bookmark

Population

Ventricular tissue (specific model not specified in abstract)

Design

Preclinical

Authors

ASAllen M. ScherUniversity of Washington AYAllan C. YoungVirginia Mason Medical Center AMARTHUR L. MALMGHENUniversity of Washington

Discussion

Member takes

Implication

Should not change clinical activation mapping; supports consensus endocardial-spread model in animals while leaving human translation open.

Key Points

To determine the pathway, speed, and spatial distribution of electrical impulse conduction through the ventricular wall.
Utilized multipolar recording techniques to measure electrical excitation through ventricular tissue.
Constructed three-dimensional isochronous planes within tissue blocks to visualize the direction and timing of impulse propagation.
Demonstrated rapid electrical conduction along the endocardium followed by slower syncytial spread across the full thickness of the ventricular wall.
Identified no evidence of electrical impulses propagating preferentially through individual cardiac muscle bundles.

Structured PICO

Population

Ventricular tissue (specific model not specified in abstract)

Intervention

Multipolar recording technics

Outcome

Spread of excitation through the wall of the ventriclesurrogate

This basic electrophysiology study demonstrates that ventricular excitation spreads rapidly along the endocardium followed by slower syncytial spread through the ventricular wall.

Cite This Study

Scher et al. (1953) studied this question.

synapsesocial.com/papers/6a1d199828423f2ce504c712 https://doi.org/10.1161/01.res.1.6.539

View Full Paper

Ask AI

Bookmark

November 1, 1953Circulation ResearchOpen Access

Spread of Electrical Activity Through the Wall of the Ventricle

View Full Paper

Ask AI

Bookmark

Population

Ventricular tissue (specific model not specified in abstract)

Design

Preclinical

Authors

ASAllen M. ScherUniversity of Washington AYAllan C. YoungVirginia Mason Medical Center AMARTHUR L. MALMGHENUniversity of Washington

Discussion

Member takes

Implication

Should not change clinical activation mapping; supports consensus endocardial-spread model in animals while leaving human translation open.

Key Points

To determine the pathway, speed, and spatial distribution of electrical impulse conduction through the ventricular wall.
Utilized multipolar recording techniques to measure electrical excitation through ventricular tissue.
Constructed three-dimensional isochronous planes within tissue blocks to visualize the direction and timing of impulse propagation.
Demonstrated rapid electrical conduction along the endocardium followed by slower syncytial spread across the full thickness of the ventricular wall.
Identified no evidence of electrical impulses propagating preferentially through individual cardiac muscle bundles.

Structured PICO

Population

Ventricular tissue (specific model not specified in abstract)

Intervention

Multipolar recording technics

Outcome

Spread of excitation through the wall of the ventriclesurrogate

This basic electrophysiology study demonstrates that ventricular excitation spreads rapidly along the endocardium followed by slower syncytial spread through the ventricular wall.

Cite This Study

Scher et al. (1953) studied this question.

synapsesocial.com/papers/6a1d199828423f2ce504c712 https://doi.org/10.1161/01.res.1.6.539

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark