What question did this study set out to answer?

This research investigates how the excitation spreads through atrial muscles near the A-V ring.

January 1, 1965Japanese Heart JournalOpen Access

Stimulus Conduction in Atria Studied by Means of Intracellular Microelectrode

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This research investigates how the excitation spreads through atrial muscles near the A-V ring.
Used intracellular microelectrode technique to record depolarization events near the A-V ring.
Compared membrane action potentials with unipolar lead electrograms to assess conduction dynamics.
Decreased depolarization rate and amplitude were observed as proximity to the A-V ring increased.
Membrane action potentials showed shapes similar to the A-V node's, indicating localized slow depolarization.
The onset of the deflections in the electrogram correlated with the sharp upstroke of the membrane action potential.

Structured PICO

Population

12 healthy adult mongrel dogs (5.0-10.0 kg) and 5 healthy adult rabbits (2.0-2.9 kg) used for isolated heart preparations.

Intervention

Intracellular microelectrode recording of transmembrane potentials in the atrial musculature near the A-V ring under artificial electric driving or natural sinus rhythm.

Outcome

Electrophysiological characteristics of the spread of excitation, including depolarization rate, amplitude of depolarization upstroke, and conduction velocity in the vicinity of the A-V ring.surrogate

The study demonstrates that atrial excitation is interrupted at the A-V ring due to progressive decreases in depolarization rate and amplitude in the adjacent musculature.

Discussion

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Implication

Indicates potential AV ring conduction barrier in mammals; leaves open relevance to human AV nodal physiology.

Cite This Study

Maretsugu Horiba (1965) studied this question.

synapsesocial.com/papers/6a2285f5f4540fbb24541121 https://doi.org/10.1536/ihj.6.59

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Stimulus Conduction in Atria Studied by Means of Intracellular Microelectrode

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Stimulus Conduction in Atria Studied by Means of Intracellular Microelectrode

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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