Why the study?
Are known rheumatoid arthritis susceptibility loci associated with anti-CCP negative disease compared to healthy controls?
Population
UK Caucasian patients with rheumatoid arthritis and 13,009 healthy controls
Comparison
HLA-DRB1 genotypes and 36 single nucleotide… vs Healthy controls
Design
Case-control
Authors
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Supports distinct genetic profiles in anti-CCP RA subsets; leaves open whether this informs prognosis or targeted therapies.
Are known rheumatoid arthritis susceptibility loci associated with anti-CCP negative disease compared to healthy controls?
Anti-CCP positive and negative rheumatoid arthritis have different genetic susceptibility profiles, suggesting they may be genetically distinct subsets.
Viatte et al. (2012) studied this question.
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