Key result
The presence of the HLA-DRB1*0401 allele was significantly associated with an increased risk of producing anti-VCP2 antibodies (OR 2.4) in patients with rheumatoid arthritis.
Odds Ratio: 2.4 (95% CI 1.261–4.566)
p-value: p=0.007
The immune response to viral citrullinated peptides in rheumatoid arthritis is associated with HLA-DRB1 shared epitope alleles, despite a lack of direct binding between the peptides and HLA molecules in vitro.
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Should not guide RA management; leaves open HLA-DRB1*0401 links to anti-VCP2 immunity.
Pratesi et al. (2012) conducted a letter in Rheumatoid Arthritis (n=172). HLA-DRB1*0401 allele vs. Non-carriers of HLA-DRB1*0401 allele was evaluated on Production of anti-VCP2 antibodies (OR 2.4, 95% CI 1.261-4.566, p=0.007). The presence of the HLA-DRB1*0401 allele was significantly associated with an increased risk of producing anti-VCP2 antibodies (OR 2.4) in patients with rheumatoid arthritis.
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